There are different mechanisms through which chromosomal position effect
There are different mechanisms through which chromosomal position effect (CPE) can result in developing human abnormalities: juxtaposition of one gene with the enhancer of another gene, separation of the transcription unit from an essential distant regulatory element, competition for the same regulatory element, or classical PEV where a gene is transferred to a new chromatin environment. Pathogenesis associated with CPE can be found in various cancers, or constitutional pathologies, in which chromosomal rearrangements (translocations, deletions, or inversions) take place.
A) Burkitt’s lymphoma t(8;14)(q24;q32) can be developed due to chromosomal translocations juxtaposing the c-myc gene on chromosome 8 to one of the immunoglobulin loci. This aggressive B-cell neoplasm is characterized by c-MYC gene placed near the enhancer of the heavy chain of immunoglobulin on chromosome 14, which results in overexpression of c-MYC in B cells. This type of lymphoma makes up the majority of BL.