The stone formation or urolithiasis is the complex physiochemical process involving series of various events from urinary supersaturation to stone formation
Rathod et al., 2015. Globally 12 percent of the total population of the world is suffering from the renal stone diseases Soundararajan et al., 2006. These stones can be of among all stones types calcium stones are major Williams and Wandzilak., 1989.
Improper lifestyle, high intake of animal protein in diet, low fluid intake high dietary intake of sodium and other renal associated disorder are some of the major risk factors associated with stone diseases Romero et al., 2010; Curhan, 2004. Oxidative stress also plays a key role factor in stone initiation and propagation Huang et al., 2003. Super saturation of urine, stone crystal formation, growth of stone crystals, aggregation and interaction of crystal with the cellular surface, crystal retention are the events occurring during the course of stone formation Finlayson et al., 1984; Khan et al., 1996.
Stones are often managed if they’re diagnosed and treated properly. Various medicinal system are used for treatment of stones. But still they are not as much effective specially in case of prevention and stone reoccurrence. Surgery is that the solely prime treatment for breaking larger stones. but the possibilities of reoccurrence aren’t altered. They might be showing several side effects Long et al., 2007.Hence the explore for antilithatic medicine from natural sources has assumed bigger importance. Many indian plants traditionally been used as antilithiatic agents. They’re effective with fewer side effects and also are cheap. Thus the indian plants are perpetually being evaluated for potential antilithiatic effects in a systematic manner Christiana et al., 2002.
Anogeissus latifolia (Syn. Conocarpus latifolius Family: Combretaceae) is well known plant used all over the world in folk medicine for various purposes. Traditionally stem bark of this plant is used in treatment of skin diseases, urinary discharge, piles and in anemia Roy et al., 1986; Kirtikar and Basu,1975.According to C.P khare this plant is also used in treating dysuria and urinary disorders Khare, 2007.Therefore, the present study proposes to investigate the antilithatic (anti-crystallization) and antioxidant activity of stem bark of Anogeissus latifolia using in-vitro models.